Www.Buycannabidiolcbdoil.Com For Sleep

Although sleep is essential for our health, its biological purpose is not fully understood. Oddly, the seemingly inactive state of sleep is really a dynamic and critical method that helps us store memories, build immunity, repair tissue, regulate metabolic process blood pressure level, control appetite and blood glucose, and process learning, plus a multitude of other physiological processes – all of which are regulated by the endocannabinoid system (ECS).

Based on the National Institute of Neurological Disorders and Stroke on the National Institute of Health (NIH), new findings suggest “sleep plays a housekeeping role that removes toxins in your brain that build-up while you are awake.”

Poor sleep is the top reported medical complaint within the Unites States as well as a serious public health concern. The normal adult needs between seven and eight hours of sleep per day. Yet, 10-30 million Americans regularly don’t get enough sleep.

Individuals with chronic illnesses are in higher risk for insomnia, which exacerbates their discomfort. Comorbid medical disorders – including issues that cause hypoxemia (abnormally low blood oxygen levels) and dyspnea (difficult or labored breathing), gastroesophageal reflux disease, pain, and neurodegenerative diseases – use a 75-95 percent increased risk of insomnia.

In 2016, in accordance with the industry research firm MarketsandMarkets, Americans spent $3.38 billion on prescription sedatives and hypnotics, over the counter (OTC) sleep drugs, and herbal sleep aids. It’s projected that the market for such products are experiencing regarding a 4.5 percent growth rate between now and 2021.

The search for good night’s sleep could be hazardous to one’s health. Daniel F. Kripke, MD, sleep expert and co-founding father of Research at Scripps Clinic Vitebri Family Sleep Center, discusses the hazards of sleep aids in his paper “Hypnotic drug risks of mortality, infection, depression, and cancer: but absence of benefit.”

Dr. Kripke reviewed 40 studies conducted on prescription sleeping pills, including hypnotic drugs including zolpidem (Ambien, Edlmar, Intermezzo and Zolpimist), temazepam (Restoril), eszopiclone (Lunesta), zaleplon (Sonata), triazolam (Halcion), flurazepam (Dalmane and Dalmadorm), quazepam, and other barbiturates utilized for sleep. Of such 40 studies, thirty-nine discovered that consumption of hypnotics is “associated with excess mortality” to the tune of a 4.6 times higher risk of death for hypnotic users.

Grim statistics: 10,000 deaths annually are directly caused by and associated with hypnotic drugs, based on medical examiner data. However, large epidemiological studies suggest the quantity of fatalities may actually be closer to 300,000-500,000 annually. The real difference may be attributed to underreported utilization of hypnotics during the time of death and the reality that prescription hypnotics are rarely listed as the cause of death.

Dr. Kripke concludes that even limited use of sleeping pills causes “next day functional impairment,” increases probability of “on-the-road driver-at-fault crashes,” increases falls and accidental injuries especially among seniors, is assigned to “2.1 times” as much new depression incidents in comparison to randomized placebo recipients, and increases the risk of suicide. Furthermore, the use of opioids along with hypnotics – two known dose-dependent respiratory suppressants – can be very dangerous, especially when mixed with alcohol along with other drugs.1

Given the problems with conventional soporifics, medical scientists have already been exploring different ways to improve sleep by targeting the endocannabinoid system (ECS). Because the primary homeostatic regulator of human physiology, the ECS plays a major role within the sleep-wake cycle and other circadian processes.

Italian scientist Vicenzo DiMarzo summarized the broad regulatory function of the endocannabinoid system within the phrase “Eat, sleep, relax, protect and forget.”

There are two types of sleep: non-rapid eye movement sleep (NREM), that has three stages, and rapid eye-movement (REM) sleep, which can be their own stage of sleep. A full sleep cycle occurs five to six times per night. The first full cycle of the night is 70-100 minutes with remaining cycles lasting 90-120 minutes each. The stages of sleep based on the National Institute of Neurological Disorders & Stroke are the following:

Stage 1 NREM sleep will be the changeover from wakefulness to get to sleep. During this short period (lasting several minutes) of relatively light sleep, your heartbeat, breathing, and eye movements slow, as well as your muscles relax with occasional twitches. Your brain waves begin to slow off their daytime wakefulness patterns.

Stage 2 NREM sleep is a time period of light sleep before you decide to enter deeper sleep. Your heartbeat and breathing slow, and muscles relax even further. The body temperature drops and eye movements stop. Brain wave activity slows but is marked by brief bursts of electrical activity. You would spend more of your repeated sleep cycles in stage 2 sleep when compared to other sleep stages.

Stage 3 NREM sleep will be the duration of deep sleep (slow-wave sleep) that you need to feel refreshed in the morning. It occurs in longer periods throughout the first half of the night. Your heartbeat and breathing slow with their lowest levels during sleep. Your muscles are relaxed, the human brain waves become even slower, it is difficult to waken throughout this cycle. This is when our bodies is stimulating growth and development, repairing muscle tissues, boosting the defense mechanisms, and building energy for the following day.

Stage 4 REM sleep initially occurs about 90 minutes after drifting off to sleep. The eyes move rapidly back and forth behind closed eyelids. Mixed frequency brain wave activity becomes nearer to that observed in wakefulness. Your breathing becomes faster and irregular, along with your heartbeat and blood pressure levels increase to near waking levels. The majority of your dreaming occurs during REM sleep (although dreams may also happen in non-REM sleep). Your arm and leg muscles become temporarily paralyzed, which prevents you against acting out your dreams. This stage is when you process whatever you have discovered your day before and consolidate memories. When you age, you sleep a smaller amount of your time in REM sleep.

How we get to sleep, stay asleep, awaken, and remain awake is part of the internal biological process regulated by our circadian rhythms and our endocannabinoid system. Circadian rhythms govern a diverse array of actions within the body, including hormone production, heartrate, metabolism, so when to go to sleep and get up.

It’s as if we now have an inside biochemical timer or clock that keeps tabs on our requirement for sleep, guides your body to get to sleep and then influences the intensity of sleep. This biological mechanism is impacted by external forces including travel, medication, food, drink, environment, stress and more. Key question: Does the endocannabinoid system regulate our experience with circadian rhythms or the other way around?

Proof of a strong relationship involving the two is observed in the sleep-wake cycle fluctuations of anandamide and 2-AG (the brain’s own marijuana-like molecules), together with the metabolic enzymes that create and break down these endogenous cannabinoid compounds.

Anandamide is found within the brain at higher levels at night and it also works with the endogenous neurotransmitters oleamide and adenosine to generate sleep. Conversely, 2AG is higher during the day, suggesting that it is involved with promoting wakefulness.

The highly complex sleep-wake cycle is driven by a number of neurochemicals and molecular pathways.2 Both anandamide and 2AG activate CB1 cannabinoid receptors which can be concentrated within the central nervous system, including areas of the mind connected with regulating sleep.

CB1 receptors modulate neurotransmitter release in a manner that dials back excessive neuronal activity, thereby reducing anxiety, pain, and inflammation. CB1 receptor expression is thus a vital factor in modulating sleep homeostasis.

This is simply not the situation, however, with respect to the CB2, the cannabinoid receptor located primarily in immune cells, the peripheral nervous system, and metabolic tissue. Whereas CB1 receptor expression reflects cyclical circadian rhythms, no such fluctuations happen to be described for the CB2 receptor.

The challenge of studying and treating sleep disturbances is complicated by the fact that sleep disorders are symptomatic of numerous chronic illnesses. In many cases, poor sleep leads to chronic illness, and chronic illness always involves an actual imbalance or dysregulation of the endocannabinoid system. Although we still have much to learn about the connection in between the ECS and circadian rhythms, it’s clear that adequate quality sleep is really a critical element of restoring and maintaining one’s health.

Cannabinoids happen to be used for centuries to market sleepiness and to assist stay asleep. Inside the acclaimed medical reference Materia Medica, published inside the 18th century, cannabis was listed as a ‘narcotica’ and ‘anodyna’ (pain reliever). Its reintroduction to Western medicine by Sir William B. O’Shaughnessy in 1843 triggered studies that underscored the remedial properties of “Indian hemp” for sleep disorders.

“Of all anaesthetics ever proposed, Indian hemp is definitely the one that produced a narcotism most closely resembling natural sleep without causing any extraordinary excitement of the vessels, or any particular suspension of secretions, or without fear of a dangerous reaction, and consecutive paralysis,” German researcher Bernard Fronmueller observed in 1860. Nine years later Fronmueller reported that in 1000 patients with sleep disturbance, Indian hemp produced cures in 53 percent, partial cure in 21.5 percent, and little or no effects in 25.5 percent.

Sleep-related problems carry on and drive a large percentage of individuals to seek relief with cannabis. Poor sleep and lack of sleep cause physiological changes within the body after only one night, leading to slower reaction times, deceased cognitive performance, less energy, aggravated pain and vtkvnz inflammation, and even overeating or cravings for top-fat, high-carbohydrate “comfort” foods. A 2014 study by Babson et al notes that approximately fifty percent of long-term cannabis consumers (over 10 years) report using cannabis as being a sleep aid. Among medical marijuana patients, 48 percent report using cannabis to assist with insomnia.

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